7-aminocoumarin

Names

[ CAS No. ]:
19063-57-1

[ Name ]:
7-aminocoumarin

[Synonym ]:
7-Amino-2H-chromen-2-one
2H-1-Benzopyran-2-one, 7-amino-
7-Amino-2H-1-benzopyran-2-one
7-aminocoumarin
2H-1-Benzopyran-2-one,7-amino
7-amino coumarin
7-amino-chromen-2-one
7-Amino-cumarin

Biological Activity

[Description]:

7-Aminocoumarin is a pH-insensitive blue fluorophore. 7-Aminocoumarin is widely used as laser dyes in the blue-green region. 7-Aminocoumarin can be used to tag recombinant proteins on the cell surface and inside living cells through PRIME (probe incorporation mediated by enzymes). 7-Aminocoumarin can be visualized in acidic organelles such as endosomes[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Jin X, et al. Synthesis of 7-aminocoumarin by Buchwald-Hartwig cross coupling for specific protein labeling in living cells. Chembiochem. 2011 Jan 3;12(1):65-70.

[2]. Pedone A. Role of Solvent on Charge Transfer in 7-Aminocoumarin Dyes: New Hints from TD-CAM-B3LYP and State Specific PCM Calculations. J Chem Theory Comput. 2013 Sep 10;9(9):4087-96.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
381.4±37.0 °C at 760 mmHg

[ Melting Point ]:
207-210°C (lit.)

[ Molecular Formula ]:
C₉H₇NO₂

[ Molecular Weight ]:
161.157

[ Flash Point ]:
219.3±24.0 °C

[ Exact Mass ]:
161.047684

[ PSA ]:
56.23000

[ LogP ]:
0.09

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.659

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932209090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%