LMPTP inhibitor 23

Names

[ CAS No. ]:
1908414-82-3

[ Name ]:
LMPTP inhibitor 23

[Synonym ]:
MFCD31536319
Benzamide, N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]-
N,N-Diethyl-4-(4-{[3-(1-piperidinyl)propyl]amino}-2-quinolinyl)benzamide

Biological Activity

[Description]:

LMPTP inhibitor 23 is a potent, selective, orally bioavailable low-molecular-weight protein tyrosine phosphatase (LMPTP) inhibitor with IC50 of 0.8 uM; displays exquisite selectivity for LMPTP versus other PTPs including PTP1B, shows greater potency on LMPTP-A versus LMPTP-B; inhibits uncompetitively LMPTP with Ki of 846 nM, substantially increases HepG2 IR phosphorylation after insulin stimulation and reversess diabetes in mice without causing overt toxicity or weight loss.

[References]

References 1. Stanford SM, et al. Nat Chem Biol. 2017 Jun;13(6):624-632. View Related Products by Target Protein Phosphatase/PTP

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
657.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₆N₄O

[ Molecular Weight ]:
444.612

[ Flash Point ]:
351.6±31.5 °C

[ Exact Mass ]:
444.288910

[ LogP ]:
4.87

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.613

LMPTP inhibitor 23

Names

Biological Activity

Chemical & Physical Properties

Related Compounds