N-METHYLISATIN-3-THIOSEMICARBAZONE

Names

[ CAS No. ]:
1910-68-5

[ Name ]:
N-METHYLISATIN-3-THIOSEMICARBAZONE

[Synonym ]:
Metisazon
Viruzona
Metisazonum
N-methylisatin-3-thiosemicarbazone
methisazone
[(1-methyl-2-oxoindol-3-ylidene)amino]thiourea
[(Z)-(1-methyl-2-oxoindol-3-ylidene)amino]thiourea
Marboran
N-Methylisatin thiosemicarbazone
Kemoviran

Biological Activity

[Description]:

Methisazone (Marboran) is an antiviral agent that works by inhibiting mRNA and protein synthesis. Methisazone is also a SARS-CoV-2 (COVID-19) inhibitor. Methisazone is mainly used in pox viruses[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[References]

[1]. Bhumi Shah, et al. In silico studies on therapeutic agents for COVID-19: Drug repurposing approach. Life Sci. 2020 Jul 1;252:117652.

Chemical & Physical Properties

[ Density]:
1.47 g/cm3

[ Boiling Point ]:
410.3ºC at 760 mmHg

[ Melting Point ]:
245°

[ Molecular Formula ]:
C₁₀H₁₀N₄OS

[ Molecular Weight ]:
234.28

[ Flash Point ]:
202ºC

[ Exact Mass ]:
234.05800

[ PSA ]:
102.81000

[ LogP ]:
1.35650

[ Vapour Pressure ]:
6.07E-07mmHg at 25°C

[ Index of Refraction ]:
1.732

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL7960000

CHEMICAL NAME :: Indole-2,3-dione, 1-methyl-, 3-(thiosemicarbazone)

CAS REGISTRY NUMBER :: 1910-68-5

LAST UPDATED :: 199106

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H10-N4-O-S

MOLECULAR WEIGHT :: 234.30

WISWESSER LINE NOTATION :: T56 BNVYJ B1 DUNMYZUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 30 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,821,1976

Safety Information

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%