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YM 976

Names

[ CAS No. ]:
191219-80-4

[ Name ]:
YM 976

[Synonym ]:
YM 976
Tocris-1821
4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one

Biological Activity

[Description]:

YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[References]

[1]. Hiroshi Moriuchi, et al. Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur J Pharmacol. 2003 May 30;470(1-2):57-64.

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
485.4ºC at 760mmHg

[ Melting Point ]:
132.7-134.0ºC(lit.)

[ Molecular Formula ]:
C17H16ClN3O

[ Molecular Weight ]:
313.78100

[ Flash Point ]:
247.4ºC

[ Exact Mass ]:
313.09800

[ PSA ]:
47.78000

[ LogP ]:
3.69420

[ Vapour Pressure ]:
1.42E-09mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
2-8°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds