Tenacissoside H

Names

[ CAS No. ]:
191729-45-0

[ Name ]:
Tenacissoside H

[Synonym ]:
(3β,5α,11α,12β,14β,17α)-12-Acetoxy-3-{[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy}-20-oxo-8,14-epoxypregnan-11-yl 2-meth ylbutanoate
Butanoic acid, 2-methyl-, (3β,5α,11α,12β,14β,17α)-12-(acetyloxy)-3-[[2,6-dideoxy-4-O-(6-deoxy-3-O-methyl-β-D-allopyranosyl)-3-O-methyl-β-D-arabino-hexopyranosyl]oxy]-8,14-ep oxy-20-oxopregnan-11-yl ester
Tenacissoside H

Biological Activity

[Description]:

Tenacissoside H is a Chinese medicine monomer extracted, isolated from Caulis Marsdeniae Tenacissimae.IC50 value:Target:In vitro: TDH significantly inhibited cells proliferation in a time-and-dose-dependent manner. TDH arrested the cell cycle in S phase and significantly inhibited PI3K and NF-κB mRNA expression, compared with blank controlled group (P < 0.05). [1]In vivo: TDH strongly inhibits tumor growth and volume. PCNA expression was significantly decreased after treatment of TDH. TDH downregulated proteins expression in PI3K/Akt-NF-κB transduction cascade (P < 0.05). [1]

[Related Catalog]:

Signaling Pathways >> Others >> Others

Natural Products >> Steroids

Research Areas >> Cancer

[References]

[1]. Jia YS, et al. Antitumor Activity of Tenacissoside H on Esophageal Cancer through Arresting Cell Cycle and Regulating PI3K/Akt-NF-κB Transduction Cascade. Evid Based Complement Alternat Med. 2015;2015:464937.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
815.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₂H₆₆O₁₄

[ Molecular Weight ]:
794.965

[ Flash Point ]:
235.5±27.8 °C

[ Exact Mass ]:
794.445251

[ PSA ]:
178.04000

[ LogP ]:
4.73

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.551

Safety Information

[ Safety Phrases ]:
24/25

[ HS Code ]:
29389090

Tenacissoside H

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds