<Suppliers Price>

RL648_81

Names

[ CAS No. ]:
1919050-87-5

[ Name ]:
RL648_81

[Synonym ]:
Carbamic acid, N-[2-amino-3-fluoro-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]-, ethyl ester
Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate
Ethyl (2-amino-3-fluoro-4-{[4-(trifluoromethyl)benzyl]amino}phenyl)carbamate
RL648_81

Biological Activity

[Description]:

RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
412.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H17F4N3O2

[ Molecular Weight ]:
371.33

[ Flash Point ]:
203.4±28.7 °C

[ Exact Mass ]:
371.125702

[ LogP ]:
1.97

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.595

Related Compounds