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Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt

Names

[ CAS No. ]:
1926163-57-6

[ Name ]:
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone trifluoroacetate salt

[Synonym ]:
L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[1-[3-[(aminoiminomethyl)amino]propyl]-4-fluoro-2,3-dioxobutyl]-
N-[(Benzyloxy)carbonyl]-L-valyl-L-arginyl-N-(7-carbamimidamido-1-fluoro-2,3-dioxo-4-heptanyl)-L-prolinamide

Biological Activity

[Description]:

Val-Arg-Pro-DL-Arg-Fluoromethylketone is a potent MALT1 inhibitor. Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits cell proliferation and migration. Val-Arg-Pro-DL-Arg-Fluoromethylketone shows anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> NF-κB >> MALT1

[Target]

MALT1[1]


[In Vitro]

Val-Arg-Pro-DL-Arg-Fluoromethylketone (75 mol/L; 6, 12, 24, 36, and 48 h) 抑制 OCI-LY10 细胞的增殖和迁移[1]。 Cell Proliferation Assay[1] Cell Line: OCI-LY10 cells Concentration: 75 mol/L Incubation Time: 6, 12, 24, 36, and 48 h Result: Inhibited the proliferation and migration of OCI-LY10 cells.

[In Vivo]

Val-Arg-Pro-DL-Arg-Fluoromethylketone (37.5 M*0.2 mL；每隔一天，持续 12 天) 抑制小鼠肿瘤的生长[1]。 Animal Model: 4-6 weeks, 16-20 g, Female BALB/c nude mice (OCI-LY10 cells)[1] Dosage: 37.5 M*0.2 mL Administration: Every other day for 12 days Result: Inhibited the growth of the xenografts and decreased the expression of P65.

[References]

[1]. Feng J, et al. Z-VRPR-FMK can inhibit the growth and invasiveness of diffuse large B-cell lymphoma by depressing NF-κB activation and MMP expression induced by MALT1. Int J Clin Exp Pathol. 2019 Jun 1;12(6):1947-1955.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C31H49FN10O6

[ Molecular Weight ]:
676.78

[ Exact Mass ]:
704.376953

[ LogP ]:
-1.05

[ Index of Refraction ]:
1.627

Related Compounds