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F-901318

Names

[ CAS No. ]:
1928707-56-5

[ Name ]:
F-901318

[Synonym ]:
1H-Pyrrole-2-acetamide, N-[4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl]-1,5-dimethyl-α-oxo-3-phenyl-
T34SH2H9HI
2-(1,5-Dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-{4-[4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl]phenyl}-2-oxoacetamide
olorofim
F-901318

Biological Activity

[Description]:

A novel antifungal agent that inhibits A. fumigatus DHODH with IC50 of 44 nM; shows little inhibition of human DHODH (>100 uM); displays excellent potency against a broad range of pathogenic filamentous and dimorphic fungi, including Penicillium spp., Coccidiodes immitis, H. capsulatum, Blastomyces dermatitidis, Fusarium spp., and the difficult-to-treat Scedosporium spp. Fungal Infection Phase 2 Clinical

[References]

References 1. Oliver JD, et al. Proc Natl Acad Sci U S A. 2016 Oct 25. pii: 201608304. 2. Wiederhold NP, et al. J Antimicrob Chemother. 2017 Mar 15. doi: 10.1093/jac/dkx065. 3. Buil JB, et al. J Antimicrob Chemother. 2017 Jun 10. doi: 10.1093/jac/dkx177. View Related Products by Target Fungal Fungal Infection

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C28H27FN6O2

[ Molecular Weight ]:
498.551

[ Exact Mass ]:
498.217957

[ LogP ]:
3.46

[ Index of Refraction ]:
1.660

Related Compounds