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Cortistatin 14, human, rat

Names

[ CAS No. ]:
193829-96-8

[ Name ]:
Cortistatin 14, human, rat

Biological Activity

[Description]:

Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767.

[2]. de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C81H113N19O19S2

[ Molecular Weight ]:
1721.01

Related Compounds