Metrizoic acid

Names

[ CAS No. ]:
1949-45-7

[ Name ]:
Metrizoic acid

[Synonym ]:
3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzoic acid
Metrizoic acid
metrizoate
3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzoic Acid
3,5-DiacetaMido-N-Methyl-2,4,6-triiodobenzoic Acid
Metrizoic
Metrizoesaeure
MFCD00867964
Triosil-280
5-Acetamino-3-<N-acetyl-methylamino>-2.4.6-triiod-benzoesaeure
EINECS 217-761-1

Biological Activity

[Description]:

Metrizoic acid (Metrizoate) is an ionic contrast medium. Metrizoic acid (Metrizoate) shows high osmolality and has a risk of inducing allergic reactions[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Vik-Mo H, et al. Hemodynamic and electrocardiographic consequences of high- and low-osmolality contrast agents for left ventricular angiography. Cathet Cardiovasc Diagn. 1988;14(3):143-9.

[2]. Sortland O, et al. Iopentol in urography. A clinical comparison between iopentol and metrizoate includingdelayed reactions. Acta Radiol. 1992 Jul;33(4):368-73.

[3]. Holtås S,et al. Contrast enhanced brain CT. Comparison between iohexol and metrizoate. Neuroradiology. 1983;24(4):213-5.

Chemical & Physical Properties

[ Density]:
2.483g/cm3

[ Boiling Point ]:
678.8ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₁I₃N₂O₄

[ Molecular Weight ]:
627.94000

[ Flash Point ]:
364.3ºC

[ Exact Mass ]:
627.78500

[ PSA ]:
86.71000

[ LogP ]:
3.21270

[ Vapour Pressure ]:
2.35E-19mmHg at 25°C

[ Index of Refraction ]:
1.77

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG0887300

CHEMICAL NAME :: Benzoic acid, 3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-

CAS REGISTRY NUMBER :: 1949-45-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C12-H11-I3-N2-O4

MOLECULAR WEIGHT :: 627.95

WISWESSER LINE NOTATION :: 1VN1&R BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 38100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >46800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 17,340,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 234 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,843,1982

Safety Information

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RTECS ]:
DG0887300

[ HS Code ]:
2924299090

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%