YKL-1-116

YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant).

References 1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481. View Related Products by Target Cyclin-dependent Kinase (CDK)