25S-Inokosterone

25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

25S-Inokosterone (10 μM) significantly promotes the proliferation of LPS-induced NRK52e cells (1.0 μg/mL LPS). 25S-Inokosterone significantly reduces the rate of NRK52e cells apoptosis[1]. 25S-Inokosterone shows weak inhibitory activity for thymus and activation-regulated chemokine expression levels in TNF-α plus IFN-γ induced HaCaT cells. 25S-Inokosterone exhibits the most potent inhibition (80-95% at 200 µg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells[3].

[1]. Shengchao Wang, et al. Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway. Biomed Pharmacother

[2]. Bing Tian Zhao, et al. High performance liquid chromatography used for quality control of Achyranthis Radix. Arch Pharm Res. 2012 Aug;35(8):1449-55.

[3]. K. Kim, et al.Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity. J Appl Biol Chem (2015) 58(1), 13-19.