6-MOMIPP
Names
[ CAS No. ]:
1961272-45-6
[ Name ]:
6-MOMIPP
Biological Activity
[Description]:
6-MOMIPP is a novel microtubule disruptor that targets the colchicine binding site on β-tubulin, induces mitotic arrest, caspase activation and loss of cell viability of U251 glioblastoma in vitro; demonstrates broad activity against the viability of multiple glioblastoma, melanoma and lung carcinoma cell lines; effectively inhibits growth of subcutaneous and intracerebral tumors without causing general toxicity in mice bearing human U251 glioblastoma xenografts .
[References]
References 1. Du S, et al. Cancer Chemother Pharmacol. 2018 Nov 13. doi: 10.1007/s00280-018-3726-1. View Related Products by Target Microtubule/Tubulin
Chemical & Physical Properties
[ Molecular Formula ]:
C18H16N2O2
[ Molecular Weight ]:
292.338