Megazol

Names

[ CAS No. ]:
19622-55-0

[ Name ]:
Megazol

[Synonym ]:
megazol
Nitroimidazole thiadiazole

Biological Activity

[Description]:

Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

EC50: 0.01 μg/mL (T. b. brueei)[1]

[In Vitro]

Megazol has effective inhibitory against T. b. brueei AnTat 1-9 with an EC50 of 0.01 μg/mL[1].

[In Vivo]

Megazol (i.p. or p.o.; 20, 80 mg/kg) shows cure the acute disease in T. b. brueei infected Swiss mice[1]. Megazol alone not causes cure of mice carrying a subacute infection with involvement of the central nervous system (CNS) [1]. Megazol have remission effect combined suramin, without further relapse from the CNS[1]. Animal Model: Swiss mice[1] Dosage: 20, 80 mg/kg Administration: i.p., p.o. Result: Cured infection at 20 mg/kg (i.p) and at 80 mg/kg (p.o).

Chemical & Physical Properties

[ Density]:
2g/cm3

[ Boiling Point ]:
532.6ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₆N₆O₂S

[ Molecular Weight ]:
226.21600

[ Flash Point ]:
275.9ºC

[ Exact Mass ]:
226.02700

[ PSA ]:
143.68000

[ LogP ]:
1.53340

[ Vapour Pressure ]:
2.01E-11mmHg at 25°C

[ Index of Refraction ]:
1.921

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI3525000

CHEMICAL NAME :: 1,3,4-Thiadiazole, 2-amino-5-(1-methyl-5-nitroimidazol-2-yl)-

CAS REGISTRY NUMBER :: 19622-55-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H6-N6-O2-S

MOLECULAR WEIGHT :: 226.24

WISWESSER LINE NOTATION :: T5NN DSJ CZ E- BT5N CNJ A1 ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Klebsiella pneumoniae

DOSE/DURATION :: 100 nmol/L/20H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 66,207,1979