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ISOX-DUAL

Names

[ CAS No. ]:
1962928-22-8

[ Name ]:
ISOX-DUAL

[Synonym ]:
ISOX-DUAL
3-(4-(2-(5-(3,5-dimethylisoxazol-4-yl)-1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)ethyl)phenoxy)-N,N-dimethylpropan-1-amine
3-[4-(2-{5-(3,5-Dimethyl-1,2-oxazol-4-yl)-1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl}ethyl)phenoxy]-N,N-dimethyl-1-propanamine
1-Propanamine, 3-[4-[2-[5-(3,5-dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]ethyl]phenoxy]-N,N-dimethyl-
3-[4-[2-[5-(3,5-Dimethyl-4-isoxazolyl)-1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]ethyl]phenoxy]-N,N-dimethyl-1-propanamine
[3-[4-[2-[5-(Dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl]phenoxy]propyl]dimethylamine

Biological Activity

[Description]:

ISOX-DUAL is a dual CBP/BRD4 inhibitor with IC50 values of 0.65 μM and 1.5 μM for CBP and BRD4, respectively[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[References]

[1]. Edmonds AK, et, al. Scale-up and optimization of the synthesis of dual CBP/BRD4 inhibitor ISOX-DUAL. Org Biomol Chem. 2022 May 18;20(19):4021-4029.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
707.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C31H41N5O3

[ Molecular Weight ]:
531.69

[ Flash Point ]:
381.7±32.9 °C

[ Exact Mass ]:
531.320923

[ LogP ]:
4.32

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds