XAC

Names

[ CAS No. ]:
1962928-23-9

[ Name ]:
XAC

Biological Activity

[Description]:

Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

IC50: 1.8 nM (Adenosine A1 receptor) IC50: 114 nM (Adenosine A2 receptor)[1]

[In Vivo]

Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1]. Animal Model: Mice[1] Dosage: 39.8 mg/kg Administration: Infusion injection; single dose Result: Acted as a convulsant agent than either caffeine or theophyllin.

[References]

[1]. P F Morgan, et al.Potent Convulsant Actions of the Adenosine Receptor Antagonist, Xanthine Amine Congener (XAC). Life Sci. 1989;45(8):719-28

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₃₀Cl₂N₆O₄

[ Molecular Weight ]:
501.41

XAC

Names

Biological Activity

Chemical & Physical Properties

Related Compounds