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Antiproliferative agent-15

Names

[ CAS No. ]:
19819-18-2

[ Name ]:
Antiproliferative agent-15

[Synonym ]:
2-Phenyl-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
2-Phenyl-5,6,7,8-tetrahydro(1)benzothieno(2,3-d)pyrimidin-4(1H)-one
2-phenyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
(1)Benzothieno(2,3-d)pyrimidin-4(1H)-one,5,6,7,8-tetrahydro-2-phenyl
[1]benzothieno[2,3-d]pyrimidin-4(3h)-one,5,6,7,8-tetrahydro-2-phenyl

Biological Activity

[Description]:

Antiproliferative agent-15 is an anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Antiproliferative agent-15 (compound 6a) shows antiproliferative activity against human colon (HCT116 and HCT15), brain (LN-229 and GBM-10) cancer cell lines, with IC50 values of 8.3 μM, 4.8 μM, 18.3 μM, and 12 μM, respectively. However, Antiproliferative agent-15 has no active against ovarian (A2780) cancer cell lines and normal cell line (CHO)[1].

[References]

[1]. Haneen Amawi, et al. Thienopyrimidine derivatives exert their anticancer efficacy via apoptosis induction, oxidative stress and mitotic catastrophe. Eur J Med Chem. 2017 Sep 29;138:1053-1065.  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H14N2OS

[ Molecular Weight ]:
282.36000

[ Exact Mass ]:
282.08300

[ PSA ]:
74.25000

[ LogP ]:
3.94270

[ Vapour Pressure ]:
2.72E-07mmHg at 25°C

[ Storage condition ]:
-20°C

Related Compounds