VK4-116

VK4-116 is a novel potent, highly selective dopamine D3 receptor (D3R) antagonist with Ki of 6.8 nM, displays >1,000-fold selectivity over D2R; inhibits oxycodone-induced hyperlocomotion in mice and reduces oxycodone-induced locomotor sensitization, also dose-dependently inhibites the acquisition of oxycodone-induced conditioned place preference (CPP) in rats.

References 1. You ZB, et al. Neuropsychopharmacology. 2018 Nov 27. doi: 10.1038/s41386-018-0284-5. 2. Kumar V, et al. J Med Chem. 2016 Aug 25;59(16):7634-50. View Related Products by Target Dopamine Receptor