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Cholesterol myristate

Names

[ CAS No. ]:
1989-52-2

[ Name ]:
Cholesterol myristate

[Synonym ]:
Cholesterol=tetradecanoate
CHOLESTERYL TETRADODEDECANOATE
EINECS 217-867-8
Cholesteryl myristate
Cholest-5-en-3-yl myristate
Cholesterol Myristate
Cholestryl myristate
MFCD00014256
Myristic Acid Cholesterol Ester
O-myristoyl-cholesterol
cholesteryl tetradecanoate
Cholestryl myristic acid
Myristinsaeure-cholesterylester

Biological Activity

[Description]:

Cholesterol myristate is a natural steroid present in traditional Chinese medicine.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Natural Products >> Steroids

[Target]

Human Endogenous Metabolite


[In Vitro]

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1].

[Cell Assay]

MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1].

[References]

[1]. Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26.

[2]. Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42.


[Related Small Molecules]

3-Methyladenine | Hydrocortisone | Acetylcysteine(N-acetylcysteine) | Retinoic acid | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Corticosterone | Progesterone | Docosahexaenoic Acid | NAD+

Chemical & Physical Properties

[ Density]:
0.95 g/cm3

[ Boiling Point ]:
630.7ºC at 760 mmHg

[ Melting Point ]:
84 °C

[ Molecular Formula ]:
C41H72O2

[ Molecular Weight ]:
597.00900

[ Flash Point ]:
334.8ºC

[ Exact Mass ]:
596.55300

[ PSA ]:
26.30000

[ LogP ]:
12.64070

[ Vapour Pressure ]:
8.15E-16mmHg at 25°C

[ Index of Refraction ]:
1.506

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

Precursor & DownStream

Precursor

DownStream

Related Compounds