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Ethosuximide-d5

Names

[ CAS No. ]:
1989660-59-4

[ Name ]:
Ethosuximide-d5

[Synonym ]:
2,5-Pyrrolidinedione, 3-(ethyl-d5)-3-methyl-
3-(2H5)Ethyl-3-methyl-2,5-pyrrolidinedione
Ethosuximide-d5

Biological Activity

[Description]:

Ethosuximide-d5 is deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic drug, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Chen X, et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51.

[3]. Sondossi K, et al. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28(5):512-8.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
265.3±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H6D5NO2

[ Molecular Weight ]:
146.20

[ Flash Point ]:
123.8±18.9 °C

[ Exact Mass ]:
146.110367

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.451

Related Compounds