FEN1-IN-4

Names

[ CAS No. ]:
1995893-58-7

[ Name ]:
FEN1-IN-4

Biological Activity

[Description]:

FEN1-IN-4 (Compound 2) is a human flap endonuclease-1 (hFEN1) inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

hFEN1[1]

[In Vitro]

FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines[1].

[References]

[1]. Jack C Exell, et al. Cellularly Active N-hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site. Nat Chem Biol. 2016 Oct;12(10):815-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₂N₂O₃

[ Molecular Weight ]:
232.24

FEN1-IN-4

Names

Biological Activity

Chemical & Physical Properties

Related Compounds