Caulophylline hydriodide
Names
[ CAS No. ]:
20013-22-3
[ Name ]:
Caulophylline hydriodide
[Synonym ]:
(1R)-3-methyl-1,2,3,4,5,6-hexahydro-1r,5c-methano-pyrido[1,2-a][1,5]diazocin-8-one,hydriodide
(1R)-3-Methyl-1,2,3,4,5,6-hexahydro-1r,5c-methano-pyrido[1,2-a][1,5]diazocin-8-on,Hydroiodid
N-Methylcytisine hydriodide
C12H17N2O.I
N-methylcytisine,monohydroiodide,(1R-cis)-isomer
CYTISINE,12-METHYL-,HYDROGEN IODIDE
Caulophylline,monohydriodide (8CI)
1,5-Methano-2H-pyrido[1,2-a][1,5]diazocinium, 1,3,4,5,6,8-hexahydro-12-methyl-8-oxo-, iodide (1:1)
Caulophyllinehydriodide
Caulophylline,monohydriodide
(-)-7R:9S-Caulophylline hydrogen iodide
13-Methyl-6-oxo-11-aza-7-azoniatricyclo[7.3.1.0]trideca-2,4-diene iodide
Chemical & Physical Properties
[ Boiling Point ]:
408.9ºC at 760 mmHg
[ Molecular Formula ]:
C12H17IN2O
[ Molecular Weight ]:
332.181
[ Flash Point ]:
201.1ºC
[ Exact Mass ]:
332.038544
[ PSA ]:
34.03000
[ LogP ]:
2.12800
[ Vapour Pressure ]:
6.75E-07mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HA4550000
- CHEMICAL NAME :
- Cytisine, 12-methyl-, hydrogen iodide
- CAS REGISTRY NUMBER :
- 20013-22-3
- LAST UPDATED :
- 199207
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C12-H16-N2-O.H-I
- MOLECULAR WEIGHT :
- 332.21
- WISWESSER LINE NOTATION :
- T C666 A GVN LM&TTJ &IH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >830 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
- REFERENCE :
- BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
- REFERENCE :
- BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
Safety Information
[ Hazard Codes ]:
Xn