ITSA-1

Names

[ CAS No. ]:
200626-61-5

[ Name ]:
ITSA-1

[Synonym ]:
ITSA-1
Inhibitor of Trichostatin A 1
Inhibitor-1 of Trichostatin A

Biological Activity

[Description]:

ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. target：TSA.In vitro: ITSA1 (50 M) suppresses TSA-induced (300 nM) histone and tubulin acetylation in A549 cells. In vitro HDAC assay using total HeLa cell lysate as the source of enzymatic activity. ITSA1 does not affect HDAC activity in the presence or absence of TSA. ITSA1 Suppresses TSA-Activated Transcription in Murine ES Cells.

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC

[References]

[1]. Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
483.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₃H₇Cl₂N₃O

[ Molecular Weight ]:
292.12000

[ Flash Point ]:
246.2ºC

[ Exact Mass ]:
290.99700

[ PSA ]:
47.78000

[ LogP ]:
3.42660

[ Vapour Pressure ]:
1.68E-09mmHg at 25°C

[ Index of Refraction ]:
1.706

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%