3-CPs

Names

[ CAS No. ]:
20073-24-9

[ Name ]:
3-CPs

[Synonym ]:
ethyl 7-oxofuro[3,2-g]chromene-6-carboxylate
7-oxo-7H-furo[3,2-g]chromene-6-carboxylic acid ethyl ester
EINECS 243-498-7
7H-Furo(3,2-g)(1)benzopyran-6-carboxylic acid,7-oxo-,ethyl ester
3-carbethoxysporalen
3-carbethoxy psoralene
7-Oxo-7H-furo[3,2-g]chromen-6-carbonsaeure-aethylester
3-CPs
ethyl 7-oxo-7H-furo[3,2-g][1]benzopyran-6-carboxylate
3-Ethoxycarbonylpsoralen
7-Oxo-7H-furo(3,2-g)(1)benzopyran-6-carboxylic acid ethyl ester
3-ethoxycarbonylfurocoumarin
3-CARBETHOXYPSORALEN
Ethyl 3-psoralencarboxylate

Biological Activity

[Description]:

3-CPs is a serotype capsular polysaccharide which can interfere with antibody-mediated bacterial killing.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Infection

[In Vitro]

3-CPs displays protective effect against UVB damage in all concentrations tested[1]. About 50% inhibition of bacterial killing is observed when 12 ng of purified type 3 CPS is added to the OPKA. The addition of 30 μL of mouse serum post-i.p. infection with WU2 (containing 0.4 to 0.7 μg/mL released type 3 CPS) shows 26% to 52% inhibition of bacterial killing, comparable to what is observed when an equivalent amount of purified CPS is added[2].

[Kinase Assay]

To measure the inhibitory effect of releaseing type 3-CPs on bacteria killing, an OPKA is performed with the addition of culture supernatant or mouse serum obtained at 24 h following i.p. injection with 103 CFU of the S. pneumoniae WU2 strain. In each well, 10 μL of diluted rabbit serum is mixed with 10 μL of strain WU2 (1,000 CFU) and 10 μL of culture supernatant or mouse serum for 30 min at room temperature before HL-60 cells and complement are added. The percent inhibition of bacterial killing is compared to that with the OPKA with the addition of ΔCPS WU2 culture supernatant or naive mouse serum containing no 3-CPs[2].

[References]

[1]. Silva EB, et al. Modulation of the UVB-induced lethality by furocoumarins in Staphylococcus aureus. J Photochem Photobiol B. 2014 Jan 5;130:260-3. doi: 10.1016/j.jphotobiol.2013.11.012.

[2]. Choi EH, et al. Capsular Polysaccharide (CPS) Release by Serotype 3 Pneumococcal Strains Reduces the Protective Effect of Anti-Type 3 CPS Antibodies.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.387g/cm3

[ Boiling Point ]:
437.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₁₀O₅

[ Molecular Weight ]:
258.22600

[ Flash Point ]:
218.3ºC

[ Exact Mass ]:
258.05300

[ PSA ]:
69.65000

[ LogP ]:
2.71590

[ Vapour Pressure ]:
7.54E-08mmHg at 25°C

[ Index of Refraction ]:
1.621

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%