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n-(9-fluorenylmethoxycarbonyl)-l-leucin&

Names

[ CAS No. ]:
200937-57-1

[ Name ]:
n-(9-fluorenylmethoxycarbonyl)-l-leucin&

[Synonym ]:
L-Leucine-15N,N-Fmoc
Fmoc-Leu-OH-15N
MFCD00209748

Biological Activity

[Description]:

Fmoc-leucine-15N is a 15N-labeled and 13C-labled EIDD-1931. EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine ence

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[75].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-242.

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-242.

Chemical & Physical Properties

[ Melting Point ]:
152-156ºC(lit.)

[ Molecular Formula ]:
C21H2315NO4

[ Molecular Weight ]:
354.41

[ Exact Mass ]:
354.16000

[ PSA ]:
75.63000

[ LogP ]:
4.41530

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds