GS-2989

Names

[ CAS No. ]:
2013-58-3

[ Name ]:
GS-2989

[Synonym ]:
meclocyline
Meclocycline(usan)
GS-2989
Meclocycline base
Chlormethylenecycline

Biological Activity

[Description]:

Meclocycline is a tetracycline derivative. The main target of tetracyclines is the bacterial ribosome[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Fuoco D. Cytotoxicity induced by tetracyclines via protein photooxidation[J]. Advances in Toxicology, et al. Cytotoxicity induced by tetracyclines via protein photooxidation[J]. Advances in Toxicology, 2015, 2015.

Chemical & Physical Properties

[ Density]:
1.72g/cm3

[ Boiling Point ]:
716.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₁ClN₂O₈

[ Molecular Weight ]:
476.86

[ Flash Point ]:
387.1ºC

[ Exact Mass ]:
476.09900

[ PSA ]:
181.62000

[ LogP ]:
0.91580

[ Vapour Pressure ]:
0mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI7830000

CHEMICAL NAME :: 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octah ydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-

CAS REGISTRY NUMBER :: 2013-58-3

LAST UPDATED :: 198803

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H21-Cl-N2-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1022,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1022,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 425 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GICTAL Giornale Italiano di Chemioterapia. Italian Journal of Chemotherapy. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1954- Volume(issue)/page/year: 17,276,1970