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L-Leucine-13C6

Names

[ CAS No. ]:
201740-84-3

[ Name ]:
L-Leucine-13C6

[Synonym ]:
MFCD00144634
(S)-2-Amino-4-methylpentanoic acid-13C6
13C Labeled L-leucine
L-Leucine-13C6
SILAC Amino Acid
L-(13C6)Leucine

Biological Activity

[Description]:

L-Leucine-13C6 is the 13C labeled L-Leucine[1]. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[2].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.  

[3]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 229(1):77.  

[4]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb61(2):409-17.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Molecular Formula ]:
13C6H13NO2

[ Molecular Weight ]:
137.129

[ Exact Mass ]:
137.114761

[ Index of Refraction ]:
1.463

Related Compounds