Benzeneacetamide, a-hydroxy-a-methyl-

Names

[ CAS No. ]:
2019-68-3

[ Name ]:
Benzeneacetamide, a-hydroxy-a-methyl-

[Synonym ]:
(+-)-atrolactinic acid amide
(+-)-Atrolactinsaeure-amid
Atrolactamide
M-144
2-Hydroxy-2-phenylpropionamid
Themisone
(+-)-2-Hydroxy-2-phenyl-propionsaeure-amid
(rac)-Altrolactinsaeureamid
2-hydroxy-2-phenyl-propionic acid amide

Biological Activity

[Description]:

Atrolactamide (M-144) is a potent anticonvulsant. Atrolactamide can be used for the research of epilepsy[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Schenck HA,et al. Design, synthesis and evaluation of novel hydroxyamides as orally available anticonvulsants. Bioorg Med Chem. 2004 Mar 1;12(5):979-93.

Chemical & Physical Properties

[ Density]:
1.197g/cm3

[ Boiling Point ]:
349.3ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₁NO₂

[ Molecular Weight ]:
165.19

[ Flash Point ]:
165ºC

[ Exact Mass ]:
165.07900

[ PSA ]:
63.32000

[ LogP ]:
1.07970

[ Vapour Pressure ]:
1.78E-05mmHg at 25°C

[ Index of Refraction ]:
1.567

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO6284050

CHEMICAL NAME :: Mandelamide, alpha-methyl-

CAS REGISTRY NUMBER :: 2019-68-3

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H11-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 64,679,1956

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%