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JQ-1 carboxylic acid

Names

[ CAS No. ]:
202592-23-2

[ Name ]:
JQ-1 carboxylic acid

[Synonym ]:
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-
[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid
JQ-1 (carboxylic acid)

Biological Activity

[Description]:

JQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Research Areas >> Cancer

[References]

[1]. James Elliott Bradner, et al. Male contraceptive compositions and methods of use. Patent WO 2011143657 A1.


[Related Small Molecules]

(+)-JQ1 | GSK126 | Tazemetostat (EPZ-6438) | Birabresib (OTX015) | A 485 | Curcumin | ARV-771 | ARV-825 | I-BET762 | BI 2536 | GSK343 | C646 | 3-Deazaneplanocin A (hydrochloride) | I-BET151 | 666-15

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
661.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H17ClN4O2S

[ Molecular Weight ]:
400.882

[ Flash Point ]:
353.9±34.3 °C

[ Exact Mass ]:
400.076080

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.737

[ Storage condition ]:
2-8℃

Related Compounds