PKC-IN-6c

A novel, potent, brain permeant PKC inhibitor with IC50 of 80 nM, without detectable binding to the estrogen receptor (Ki>10 uM); effectively blocks amphetamine-induced locomotor stimulation, more potently inhibits PKC than tamoxifen and reduces amphetamine-stimulated dopamine efflux.

References 1. Newman AH, et al. Neuropsychopharmacology. 2017 Jun 8. doi: 10.1038/npp.2017.116. View Related Products by Target PKC