BMS-192364

Names

[ CAS No. ]:
202822-21-7

[ Name ]:
BMS-192364

[Synonym ]:
unii-1nc8d8p7qf

Biological Activity

[Description]:

BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Signaling Pathways >> GPCR/G Protein >> RGS Protein
Research Areas >> Neurological Disease

[References]

[1]. Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57.  

[2]. Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38(4):344-54.  

[3]. David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80(3):233-5.  

Chemical & Physical Properties

[ Molecular Formula ]:
C15H9ClF3N3O2

[ Molecular Weight ]:
355.70

[ Exact Mass ]:
355.03400

[ PSA ]:
70.91000

[ LogP ]:
3.60540

Related Compounds