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t-Boc-Aminooxy-PEG4-CH2CO2H

Names

[ CAS No. ]:
2028281-90-3

[ Name ]:
t-Boc-Aminooxy-PEG4-CH2CO2H

[Synonym ]:
MFCD30458018

Biological Activity

[Description]:

Boc-Aminooxy-PEG4-CH2CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H29NO9

[ Molecular Weight ]:
367.39

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds