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conantokin R

Names

[ CAS No. ]:
202925-60-8

[ Name ]:
conantokin R

[Synonym ]:
Glycinamide, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl &#xA;-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-[[[(1S)-2-[(2S)-2-carboxy-1-pyrrolidinyl]-1-[(4-hydroxyphenyl)m ;ethyl]-2-oxoethyl]amino]carbonyl]-10-(1-meth
Glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L- &#xA;α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-N-[(4R,7S,10S,13S,16R)-13-(4-aminobutyl)-7-(2-amino-2-oxoethyl)-4-{[(2S)-1-[(2S)-2-carboxy-1-pyrrolidinyl]-3-(4-hydroxyphenyl)-1-oxo-2-propany ;l]carbamoyl}-10-isopropyl-6,9,12,15-tetraoxo

Biological Activity

[Description]:

Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

IC50: 93 nM (NMDA receptor)[1]


[References]

[1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46.  

[2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C127H201N35O49S3

[ Molecular Weight ]:
3098.35

[ Exact Mass ]:
3096.347412

[ LogP ]:
-8.16

[ Index of Refraction ]:
1.675


Related Compounds