(±)-Coclaurine

Names

[ CAS No. ]:
2033-08-1

[ Name ]:
(±)-Coclaurine

[Synonym ]:
1-(4-hydroxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol
D,L-coclaurine
dl-coclaurine
(R,S)-coclaurine
(+/-)-coclaurine
1-(4-Hydroxy-benzyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-7-ol
(+/-)-Coclaurine

Biological Activity

[Description]:

(±)-Coclaurine is a natural product that can be found in Roemeria refracta. (±)-Coclaurine exhibits antioxidative activity and cardiovascular effects[1][2][3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[In Vitro]

(±)-Coclaurine (1 μM-1 mM) 以浓度依赖性方式松弛 KCl 诱导的主动脉环收缩[3]。

[References]

[1]. Gözler B, et, al. Epimeric Isopavine N-Oxides from Roemeria refracta. Phytotherapy Research. Helvetica. 1992 Feb 5; 75(1): 260-268.

[2]. Cassels BK, et, al. Structure-antioxidative activity relationships in benzylisoquinoline alkaloids. Pharmacol Res. 1995 Feb;31(2):103-7.  

[3]. Morales MA, et, al. Cardiovascular effects of plant secondary metabolites norarmepavine, coclaurine and norcoclaurine. Phytotherapy Research. 1998 Mar; 12(2): 103-109.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19NO3

[ Molecular Weight ]:
285.33800

[ Exact Mass ]:
285.13600

[ PSA ]:
61.72000

[ LogP ]:
2.86470

Related Compounds