IDO/TDO-IN-1

Names

[ CAS No. ]:
2033173-01-0

[ Name ]:
IDO/TDO-IN-1

Biological Activity

[Description]:

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)

[Target]

IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]

[In Vitro]

IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].

[References]

[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₄FN₅

[ Molecular Weight ]:
413.49

IDO/TDO-IN-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds