S 3304

Names

[ CAS No. ]:
203640-27-1

[ Name ]:
S 3304

[Synonym ]:
D-Tryptophan,N-((5-(2-(4-methylphenyl)ethynyl)-2-thienyl)sulfonyl)
UNII-BK459F050X
D-Tryptophan,N-((5-((4-methylphenyl)ethynyl)-2-thienyl)sulfonyl)
S 3304

Biological Activity

[Description]:

S-3304 is a novel matrix metalloproteinases (MMP) inhibitor specific for MMP-2 and MMP-9.

[Related Catalog]:

Research Areas >> Cancer

[Target]

MMP-9

[In Vitro]

S 3304 is a novel D-tryptophan derivative and a potent, orally active, noncytotoxic Matrix metalloproteinases inhibitor (MMPI). Biochemical studies show that S 3304 most potently inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors[1].

[In Vivo]

In vivo pharmacologic studies have shown that the oral administration of S 3304, at a dose range of 20 to 200 mg/kg, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 result in potent inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen[1].

[References]

[1]. Chiappori AA, et al. A phase I pharmacokinetic and pharmacodynamic study of s-3304, a novel matrix metalloproteinase inhibitor, in patients with advanced and refractory solid tumors. Clin Cancer Res. 2007 Apr 1;13(7):2091-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₀N₂O₄S₂

[ Molecular Weight ]:
464.55700

[ Exact Mass ]:
464.08600

[ PSA ]:
135.88000

[ LogP ]:
5.38350

[ Storage condition ]:
2-8℃

S 3304

Names

Biological Activity

Chemical & Physical Properties

Related Compounds