Trimethylsilyl N-(trimethylsilyl)acetimidate-d18

Names

[ CAS No. ]:
203784-65-0

[ Name ]:
Trimethylsilyl N-(trimethylsilyl)acetimidate-d18

[Synonym ]:
Ethanimidic acid, N-(trimethyl-d-silyl)-, trimethyl-d-silyl ester, (1E)-
Tris[(H)methyl]silyl (1E)-N-{tris[(H)methyl]silyl}ethanimidate
n,o-bis(trimethyl-d9-silyl)acetamide

Biological Activity

[Description]:

Trimethylsilyl N-(trimethylsilyl)acetimidate-d18 is the deuterium labeled Trimethylsilyl N-(trimethylsilyl)acetimidate[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
162.1±0.0 °C at 760 mmHg

[ Melting Point ]:
24ºC

[ Molecular Formula ]:
C₈H₃D₁₈NOSi₂

[ Molecular Weight ]:
221.540

[ Flash Point ]:
65.5±22.6 °C

[ Exact Mass ]:
221.229141

[ PSA ]:
21.59000

[ LogP ]:
3.16

[ Vapour Pressure ]:
2.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.411

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H314

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P310

[ RIDADR ]:
UN 2920 8/PG 2