Allopregnanolone-d4
Names
[ CAS No. ]:
203805-85-0
[ Name ]:
Allopregnanolone-d4
[Synonym ]:
(3α,5α,8α)-3-Hydroxy(1,2,2,3-H)pregnan-20-one
Pregnan-20-one-1,2,2,3-d, 3-hydroxy-, (3α,5α,8α)-
Biological Activity
[Description]:
Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain[1].
[Related Catalog]:
[In Vitro]
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[References]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
431.2±18.0 °C at 760 mmHg
[ Molecular Formula ]:
C21H30D4O2
[ Molecular Weight ]:
322.518
[ Flash Point ]:
183.9±13.8 °C
[ Exact Mass ]:
322.280975
[ LogP ]:
4.89
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.524