Allopregnanolone-d4

Names

[ CAS No. ]:
203805-85-0

[ Name ]:
Allopregnanolone-d4

[Synonym ]:
(3α,5α,8α)-3-Hydroxy(1,2,2,3-H)pregnan-20-one
Pregnan-20-one-1,2,2,3-d, 3-hydroxy-, (3α,5α,8α)-

Biological Activity

[Description]:

Allopregnanolone-d4 is the deuterium labeled Allopregnanolone. Allopregnanolone (Brexanolone), a metabolite of progesterone, is a positive allosteric modulator of GABAA receptors. Allopregnanolone modulates dopamine levels in the nucleus accumbens and prefrontal cortex. Allopregnanolone stimulates food intake and weight gain[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Dornellas APS, et al. Allopregnanolone Decreases Evoked Dopamine Release Differently in Rats by Sex and Estrous Stage. Front Pharmacol. 2021;11:608887. Published 2021 Jan 14.

[3]. Kimball A, et al. The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause. Psychoneuroendocrinology. 2020;112:104512.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
431.2±18.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H30D4O2

[ Molecular Weight ]:
322.518

[ Flash Point ]:
183.9±13.8 °C

[ Exact Mass ]:
322.280975

[ LogP ]:
4.89

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.524

Related Compounds