HBV Capsid inhibitor 3711

HBV Capsid inhibitor 3711 (Compound 3711) is a nonnucleosidic HBV inhibitor, inhibits hepatitis B virus replication by inducing genome-free capsid formation; decreases extracellular HBV DNA levels and intracellular DNA levels with EC50 of 1.5 and 1.9 uM in a cell model system; shows sensitivity against both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant; decreases levels of HBV DNA contained in both secreted enveloped virion and naked virus particles in supernatant, interferes with capsid formation of the core protein (Cp) assembly domain.

References 1. Feng S, et al. ACS Infect Dis. 2018 Mar 9;4(3):257-277. 2. Wang YJ, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):7061-72. View Related Products by Target HBV