MMP-9/MMP-13 INHIBITOR I

Names

[ CAS No. ]:
204140-01-2

[ Name ]:
MMP-9/MMP-13 INHIBITOR I

Biological Activity

[Description]:

MMP-9/MMP-13 Inhibitor I is a potent MMP-9 and MMP-13 inhibitor with IC50s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-9:0.9 nM (IC50)

MMP-13:0.9 nM (IC50)

MMP-1:43 nM (IC50)

MMP-3:23 nM (IC50)

MMP-7:931 nM (IC50)

[In Vitro]

MMP-9/MMP-13 Inhibitor I (化合物 35) 抑制 MMP-1、MMP-3 和 MMP-7，IC50 值分别为 43 nM、23 nM 和 931 nM[1]。

[References]

[1]. M Cheng, et al. Design and synthesis of piperazine-based matrix metalloproteinase inhibitors. J Med Chem. 2000 Feb 10;43(3):369-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₅N₃O₆S

[ Molecular Weight ]:
495.55

[ Storage condition ]:
-20°C

MMP-9/MMP-13 INHIBITOR I

Names

Biological Activity

Chemical & Physical Properties

Related Compounds