1,2-Ethanediamine,N1,N1-dimethyl-N2-phenyl-N2-(phenylmethyl)-, hydrochloride (1:1)
Names
[ CAS No. ]:
2045-52-5
[ Name ]:
1,2-Ethanediamine,N1,N1-dimethyl-N2-phenyl-N2-(phenylmethyl)-, hydrochloride (1:1)
[Synonym ]:
PHENBENZAMINE HYDROCHLORIDE
2339 R.P. hydrochloride
Compound 2339 RP
Antergan hydrochloride
N-benzyl-N',N'-dimethyl-N-phenyl-ethylenediamine,hydrochloride
Phenbenzamine chloride
N-Phenyl-N-benzyl-N',N'-dimethylethylenediamine hydrochloride
N-benzyl-N',N'-dimethyl-N-phenyl-ethylenediamine,monohydrochloride
N-Benzyl-N',N'-dimethyl-N-phenyl-aethylendiamin,Monohydrochlorid
N-Benzyl-N',N'-dimethyl-N-phenyl-aethylendiamin,Hydrochlorid
Corps 2339 R P
Chemical & Physical Properties
[ Boiling Point ]:
375.9ºC at 760 mmHg
[ Melting Point ]:
210 - 211ºC
[ Molecular Formula ]:
C17H23ClN2
[ Molecular Weight ]:
290.83100
[ Flash Point ]:
166.2ºC
[ Exact Mass ]:
290.15500
[ PSA ]:
6.48000
[ LogP ]:
4.05680
[ Vapour Pressure ]:
7.52E-06mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KV1925000
- CHEMICAL NAME :
- Ethylenediamine, N-benzyl-N',N'-dimethyl-N-phenyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 2045-52-5
- LAST UPDATED :
- 199109
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C17-H22-N2.Cl-H
- MOLECULAR WEIGHT :
- 290.87
- WISWESSER LINE NOTATION :
- 1N1&2NR&1R &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Behavioral - muscle contraction or spasticity
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 68,339,1942
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 144,887,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 325 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 27,542,1947