Propargyl-PEG8-Boc

Names

[ CAS No. ]:
2055014-96-3

[ Name ]:
Propargyl-PEG8-Boc

[Synonym ]:
2-Methyl-2-propanyl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate
MFCD28976700
4,7,10,13,16,19,22,25-Octaoxaoctacos-27-yn-1-oic acid, 1,1-dimethylethyl ester

Biological Activity

[Description]:

Propargyl-PEG7-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Noah Bell, et al. Compounds and methods for inhibiting phosphate transport. WO2012054110A2.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
528.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₄₄O₁₀

[ Molecular Weight ]:
492.600

[ Flash Point ]:
220.3±28.8 °C

[ Exact Mass ]:
492.293457

[ LogP ]:
-0.54

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Storage condition ]:
2-8°C

Propargyl-PEG8-Boc

Names

Biological Activity

Chemical & Physical Properties

Related Compounds