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Propargyl-PEG9-OH

Names

[ CAS No. ]:
2055022-35-8

[ Name ]:
Propargyl-PEG9-OH

[Synonym ]:
MFCD28976698
3,6,9,12,15,18,21,24,27-Nonaoxatriacont-29-yn-1-ol

Biological Activity

[Description]:

Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Satwik Kamtekar, et al. Modified biotin-binding proteins for immobilization. WO2019126734A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
518.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H40O10

[ Molecular Weight ]:
452.536

[ Flash Point ]:
267.1±28.7 °C

[ Exact Mass ]:
452.262146

[ LogP ]:
-3.11

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.465

Related Compounds