Capsiate

Names

[ CAS No. ]:
205687-01-0

[ Name ]:
Capsiate

[Synonym ]:
Capsiate Natura
UNII-PX8I7HG5I3
capsiate

Biological Activity

[Description]:

Capsiate, as a capsaicin analogue extracted from a non-pungent cultivar of CH-19 sweet red pepper, is an orally active agonist of TRPV1[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

[Target]

TRPV1

[In Vitro]

Capsiate evokes current responses in HEK293 cells expressing TRPV1[1].

[In Vivo]

Capsiate does not exhibit irritancy-related effects on the oral cavity or eye[1]. Capsiate (0.03~0.54 mM; s.c.) induces nociceptive responses in mice[1]. Animal Model: Male ddY-strain mice (20–24 g) [1] Dosage: 0.5 or 5 mM Administration: P.o. Result: Did not cause pungency-related behaviors.

[References]

[1]. Iida T, et al. TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiate. Neuropharmacology. 2003;44(7):958-967.

Chemical & Physical Properties

[ Boiling Point ]:
421.3±40.0 °C(Predicted)

[ Molecular Formula ]:
C₁₈H₂₆O₄

[ Molecular Weight ]:
306.39700

[ Exact Mass ]:
306.18300

[ PSA ]:
55.76000

[ LogP ]:
4.21660

Capsiate

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds