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Irampanel

Names

[ CAS No. ]:
206260-33-5

[ Name ]:
Irampanel

[Synonym ]:
Dimethyl-(2-(2-(3-phenyl-(1,2,4)oxadiazol-5-yl)phenoxy)ethyl)amine hydrochloride
UNII-R2GZD7LMYX
Irampanel [INN]
Irampanel
BIIR-561CL

Biological Activity

[Description]:

Irampanel (BIIR 561) is an AMPA receptor and voltage-dependent sodium channel blocker. Irampanel inhibits kainate-induced currents in rat cortical neurons[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

AMPA receptor


[References]

[1]. Weiser T, et al. Characterization of the anticonvulsant and neuroprotectant BIIR 561 CL in vitro: effects on native and recombinant alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):419-26.  

Chemical & Physical Properties

[ Density]:
1.145g/cm3

[ Boiling Point ]:
471.4ºC at 760mmHg

[ Molecular Formula ]:
C18H19N3O2

[ Molecular Weight ]:
309.36200

[ Flash Point ]:
238.9ºC

[ Exact Mass ]:
309.14800

[ PSA ]:
51.39000

[ LogP ]:
3.34400

[ Vapour Pressure ]:
4.69E-09mmHg at 25°C

[ Index of Refraction ]:
1.567

Related Compounds