TRAP-6-IN-1

Names

[ CAS No. ]:
2068737-10-8

[ Name ]:
TRAP-6-IN-1

Biological Activity

[Description]:

TRAP-6-IN-1 (Compound 8) is a dual collagen and TRAP-6 inhibitor with IC50 values of 17.12 µM and 11.88 µM against collagen and TRAP-6, respectively. TRAP-6-IN-1 inhibits agonist-induced platelet aggregation in a non-competitive manner[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)

[Target]

IC50: 11.88 µM (TRAP-6), 17.12 µM (collagen)[1]


[References]

[1]. Méndez D, et al. Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6. Eur J Med Chem. 2020 Apr 15;192:112187.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H20O3

[ Molecular Weight ]:
284.35

Related Compounds