L-threo-PPMP

Names

[ CAS No. ]:
207278-87-3

[ Name ]:
L-threo-PPMP

[Synonym ]:
L-threo-PPMP

Biological Activity

[Description]:

L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

L-threo-PPMP (0.5-20 μM) induces apoptosis in carcinoma (Colo-205; SKBR3) cells after 6 h and damaging DNA between 24 and 48 h after treatment[1]. L-threo-PPMP (1-16 μM; 48 hours) includes Caspase-3 activation in breast cancer SKBR3 cells[1].

[References]

[1]. Subhash Basu, et al. Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP. Glycoconj J. 2004;20(3):157-68.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₅₀N₂O₃

[ Molecular Weight ]:
474.72

Safety Information

[ Hazard Codes ]:
Xi

L-threo-PPMP

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds