SBI-993

SBI-993 is an analog of SBI-477 that shows improved potency and suitable pharmacokinetic properties for in vivo bioavailability; reduces Txnip and Arrdc4 expression to a degree similar to that seen with SBI-477 in human myotubes; reduces muscle and liver TAG levels, enhances insulin signaling, and improved glucose tolerance in mice fed a high-fat diet.

References 1. Ahn B, et al. J Clin Invest. 2016 Sep 1;126(9):3567-79. View Related Products by Target Other Targets