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TB 21007

Names

[ CAS No. ]:
207306-50-1

[ Name ]:
TB 21007

[Synonym ]:
Methyl 2,5-dihydroxycinnamate

Biological Activity

[Description]:

TB-21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptor with a Ki of 1.6 nM. TB-21007 enhanced spatial memory in rats[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[References]

[1]. Chambers MS, et al. Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. J Med Chem. 2003 May 22;46(11):2227-40.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H17NO2S3

[ Molecular Weight ]:
339.49600

[ Exact Mass ]:
339.04200

[ PSA ]:
131.97000

[ LogP ]:
4.11110

Related Compounds