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Stigmastadienone

Names

[ CAS No. ]:
20817-72-5

[ Name ]:
Stigmastadienone

[Synonym ]:
4,22-stigmastadien-3-one
Stigmast-4,22-dien-3-one
stigmasta-4,22-dien-3-one
4,22-cholestadiene-24β-ethyl-3-one
Δ4,22-stigmasten-3-one
(8S,9S,10R,13R,14S,17R)-17-((Z)-(1R,4S)-4-Ethyl-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

Biological Activity

[Description]:

Stigmasta-4,22-dien-3-one is an antitubercular agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC50 of 0.3 mM[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Saludes JP, et al. Antitubercular constituents from the hexane fraction of Morinda citrifolia Linn. (Rubiaceae). Phytother Res. 2002 Nov;16(7):683-5.

[2]. Sandjo L P, et al. Cytotoxic effect of some pentacyclic triterpenes and hemisynthetic derivatives of stigmasterol. Chemistry of Natural Compounds, 2011, 47(5): 731-734.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H46O

[ Molecular Weight ]:
410.67500

[ Exact Mass ]:
410.35500

[ PSA ]:
17.07000

[ LogP ]:
8.00900

[ Storage condition ]:
-20°C

Related Compounds